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1

1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects

Qin Wang, Dawn Lee, Vilayvanh Sysounthone, Roshantha A.S. Chandraratna, Sylvia Christakos, Reju Korah, Robert Wieder

Journal:

Breast Cancer Research and Treatment

Year:

2001

Language:

english

File:

PDF, 294 KB

english, 2001

2

The 12-s-cis conformationally locked 11-cis-retinoids: a delineation of the thermal requirements for [1,5]-sigmatropic shifts and electrocyclizations in the vitamin A series and novel spectral properties

Chandraratna, Roshantha A. S., Bayerque, Ann L., Okamura, William H.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 955 KB

english, 1983

3

Role of retinoic acid in lens regeneration

Panagiotis A. Tsonis, Michael T. Trombley, Timothy Rowland, Roshantha A.S. Chandraratna, Katia Del Rio-Tsonis

Journal:

Developmental Dynamics

Year:

2000

Language:

english

File:

PDF, 404 KB

english, 2000

4

ChemInform Abstract: High Affinity Retinoic Acid Receptor Antagonists: Analogues of AGN 193109.

Alan T. Johnson, Liming Wang, Samuel J. Gillett, Roshantha A. S. Chandraratna

Journal:

Year:

1999

File:

PDF, 30 KB

1999

5

ChemInform Abstract: A New Class of Potent RAR Antagonists: Dihydroanthracenyl, Benzochromenyl, and Benzothiochromenyl Retinoids.

Vidyasagar Vuligonda, Andrew M. Standeven, Maria Escobar, Roshantha A. S. Chandraratna

Journal:

Year:

1999

File:

PDF, 32 KB

1999

6

ChemInform Abstract: Stereoselective Synthesis and Receptor Activity of Conformationally Defined Retinoid X Receptor Selective Ligands.

Vidyasagar Vuligonda, Michael E. Garst, Roshantha A. S. Chandraratna

Journal:

Year:

1999

File:

PDF, 31 KB

1999

7

ChemInform Abstract: A Short and Efficient Synthesis of 4-[2,2-Dimethyl-4(tol-4-yl)benzochrom-3-en-7-yl]benzoic Acid. A Potent Retinoic Acid Receptor Antagonist.

Vidyasagar Vuligonda, Roshantha A. S. Chandraratna

Journal:

Year:

1999

File:

PDF, 31 KB

1999

8

ChemInform Abstract: New Dermatological Agents for the Treatment of Psoriasis

Scott M. Thacher, Jayasree Vasudevan, Kwok-Yin Tsang, Sunil Nagpal, Roshantha A. S. Chandraratna

Journal:

Year:

2001

File:

PDF, 25 KB

2001

9

ChemInform Abstract: Phenylcyclohexene and Phenylcyclohexadiene Substituted Compounds Having Retinoid Antagonist Activity.

Richard L. Beard, Elliott S. Klein, Andrew M. Standeven, Maria Escobar, Roshantha A. S. Chandraratna

Journal:

Year:

2001

File:

PDF, 31 KB

2001

10

Synthesis and Biological Activity of Retinoic Acid Receptor-α Specific Amides.

Richard L. Beard, Tien T. Duong, Min Teng, Elliott S. Klein, Andrew M. Standevan, Roshantha A. S. Chandraratna

Journal:

Year:

2003

File:

PDF, 85 KB

2003

11

Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays

Kayo Arima, Jason Shiotsugu, Rong Niu, Ritika Khandpur, Mayra Martinez, Yongchol Shin, Tetsuya Koide, Ken W.Y. Cho, Atsushi Kitayama, Naoto Ueno, Roshantha A.S. Chandraratna, Bruce Blumberg

Journal:

Developmental Dynamics

Year:

2005

Language:

english

File:

PDF, 1.75 MB

english, 2005

12

Retinoid-related molecule AGN193198 potently induces G2M arrest and apoptosis in bladder cancer cells

Armin Reitmair, Dixie-Lee Shurland, Kwok-Yin Tsang, Roshantha A.S. Chandraratna, Geoffrey Brown

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 526 KB

english, 2005

13

1α,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms

Philip J. Hughes, Andreas Steinmeyer, Roshantha A.S. Chandraratna, Geoffrey Brown

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

14

Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

Philip J. Hughes, Yi Zhao, Roshantha A. Chandraratna, Geoffrey Brown

Journal:

Journal of Cellular Biochemistry

Year:

2006

Language:

english

File:

PDF, 377 KB

english, 2006

15

N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: Retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153

William Samuel, R. Krishnan Kutty, Sahrudaya Nagineni, Camasamudram Vijayasarathy, Roshantha A.S. Chandraratna, Barbara Wiggert

Journal:

Journal of Cellular Physiology

Year:

2006

Language:

english

File:

PDF, 418 KB

english, 2006

16

Inhibition of ectopic bone formation by a selective retinoic acid receptor α-agonist: A new therapy for heterotopic ossification?

Kengo Shimono, Tiffany N. Morrison, Wei-en Tung, Roshantha A. Chandraratna, Julie A. Williams, Masahiro Iwamoto, Maurizio Pacifici

Journal:

Journal of Orthopaedic Research

Year:

2010

Language:

english

File:

PDF, 457 KB

english, 2010

17

Selective conversion of α-tetralones to dihydronaphthalenes

Vidyasagar Vuligonda, Yuan Lin, Roshantha A.S. Chandraratna

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 192 KB

english, 1996

18

Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs

Roshantha A.S. Chandraratna, Samuel J. Gillett, Tae K. Song, John Attard, Sagar Vuligonda, Michael E. Garst, Taghreed Arefieg, Daniel W. Gil, Larry Wheeler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 244 KB

english, 1995

19

Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere

Vidyasagar Vuligonda, Yuan Lin, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 298 KB

english, 1996

20

Electronic spectra of 12-S-CIS conformationally locked retinals

Roshantha A.S. Chandraratna, Robert R. Birge, William H. Okamura

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 270 KB

english, 1984

21

12-S-CIS conformationally locked retinoids: Thermal and photochemical interconversions leading to new geometric isomers

Roshantha A.S. Chandraratna, William H. Okamura

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 271 KB

english, 1984

22

Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity

Richard L. Beard, Elliott S. Klein, Andrew M. Standeven, Maria Escobar, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

23

Synthesis and biological activity of retinoic acid receptor-α specific amides

Richard L. Beard, Tien T. Duong, Min Teng, Elliott S. Klein, Andrew M. Standevan, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 113 KB

english, 2002

24

Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid

Richard L. Beard, Min Teng, Diana F. Colon, Tien T. Duong, Scott M. Thacher, Taghreed Arefieg, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 347 KB

english, 1997

25

Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands

Vidyasagar Vuligonda, Michael E. Garst, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 257 KB

english, 1999

26

High affinity retinoic acid receptor antagonists: Analogs of AGN 193109

Alan T. Johnson, Liming Wang, Samuel J. Gillett, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 207 KB

english, 1999

27

A new class of potent rar antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids

Vidyasagar Vuligonda, Andrew M. Standeven, Maria Escobar, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 308 KB

english, 1999

28

A short and efficient synthesis of 4-[2,2-dimethyl-4(tol-4-yl)benzochrom-3-en-7-yl]benzoic acid - a potent retinoic acid receptor antagonist

Vidyasagar Vuligonda, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

29

A New Class of RAR Subtype Selective Retinoids: Correlation of Pharmacological Effects with Receptor Activity

Vidyasagar Vuligonda, Yuan Lin, Scott M. Thacher, Andrew M. Standeven, Devendra M. Kochar, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 278 KB

english, 1999

30

Synthesis and biological activity of high-affinity retinoic acid receptor antagonists

Alan T. Johnson, Liming Wang, Andrew M. Standeven, Maria Escobar, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

31

Expression and role of retinoic acid receptor alpha in lens regeneration

Panagiotis A. Tsonis, Melissa Tsavaris, Mindy K. Call, Roshantha A. S. Chandraratna, Katia Del Rio-Tsonis

Journal:

Development, Growth & Differentiation

Year:

2002

Language:

english

File:

PDF, 13.71 MB

english, 2002

32

13-cis Retinoic Acid Exerts its Specific Activity on Human Sebocytes through Selective Intracellular Isomerization to All-trans Retinoic Acid and Binding to Retinoid Acid Receptors

Tsukada, Miki, Schroder, Mandy, Roos, Thomas C., Chandraratna, Roshantha A. S., Reichert, Uwe, Merk, Hans F., Orfanos, Constantin E., Zouboulis, Christos C.

Journal:

The Journal of Investigative Dermatology

Year:

2000

Language:

english

File:

PDF, 402 KB

english, 2000

33

Retinoic acid receptor α and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat

Matthias Schaier, Sabine Liebler, Kerstin Schade, Fujio Shimizu, Hiroshi Kawachi, Hermann-Joseph Grone, Roshantha Chandraratna, Eberhard Ritz, Juergen Wagner

Journal:

Journal of Molecular Medicine

Year:

2004

Language:

english

File:

PDF, 397 KB

english, 2004

34

Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids

Richard L. Beard, Diana F. Colon, Elliott S. Klein, Kimberly A. Vorse, Roshantha A.S. Chandraratna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 373 KB

english, 1995

35

Tazarotene-induced Gene 2 (TIG2), a Novel Retinoid-Responsive Gene in Skin.

Nagpal, Sunil, Patel, Sheetal, Jacobe, Heidi, DiSepio, Daniel, Ghosn, Corine, Malhotra, Monica, Teng, Min, Duvic, Madeleine, Chandraratna, Roshantha A.S.

Journal:

The Journal of Investigative Dermatology

Year:

1997

File:

PDF, 2.16 MB

1997

36

Tazarotene-Induced Gene 1 (TIG1), a Novel Retinoic Acid Receptor-Responsive Gene in Skin.

Nagpal, Sunil, Patel, Sheetal, Asano, Arisa T., Johnson, Alan T., Duvic, Madeleine, Chandraratna, Roshantha A.S.

Journal:

The Journal of Investigative Dermatology

Year:

1996

File:

PDF, 2.21 MB

1996

37

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

Shimono, Kengo, Tung, Wei-en, Macolino, Christine, Chi, Amber Hsu-Tsai, Didizian, Johanna H, Mundy, Christina, Chandraratna, Roshantha A, Mishina, Yuji, Enomoto-Iwamoto, Motomi, Pacifici, Maurizio

Journal:

Nature Medicine

Year:

2011

Language:

english

File:

PDF, 1.82 MB

english, 2011

38

BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

Hallahan, Andrew R, Pritchard, Joel I, Chandraratna, Roshantha A S, Ellenbogen, Richard G, Geyer, J Russel, Overland, Ryan P, Strand, Andrew D, Tapscott, Stephen J, Olson, James M

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 403 KB

english, 2003

39

Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype

Higuchi, Eisaku, Chandraratna, Roshantha A S, Hong, Waun K, Lotan, Reuben

Journal:

Year:

2003

Language:

english

File:

PDF, 509 KB

english, 2003

40

A novel transglutaminase activator forms a complex with type 1 transglutaminase

Sturniolo, Michael T, Chandraratna, Roshantha A S, Eckert, Richard L

Journal:

Year:

2004

Language:

english

File:

PDF, 371 KB

english, 2004

41

A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis

Balasubramanian, Sivaprakasam, Chandraratna, Roshantha A S, Eckert, Richard L

Journal:

Year:

2005

Language:

english

File:

PDF, 470 KB

english, 2005

42

Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor-β2 mRNA levels in treated embryos

Heng Jiang, Michael Gyda Iii, Douglas C. Harnish, Roshantha A. Chandraratna, Kenneth J. Soprano, D. M. Kochhar, Dianne Robert Soprano

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Year:

1994

Language:

english

File:

PDF, 636 KB

english, 1994

43

Specific Antagonist of Retinoid Toxicity in Mice

Andrew M. Standeven, Alan T. Johnson, Maria Escobar, Roshantha A.S. Chandraratna

Journal:

Toxicology and Applied Pharmacology

Year:

1996

Language:

english

File:

PDF, 112 KB

english, 1996

44

The Synthetic Retinoid AGN 193109 but Not Retinoic Acid Elevates CYP1A1 Levels in Mouse Embryos and Hepa-1c1c7 Cells

Dianne Robert Soprano, Carlo J. Gambone, Sabina N. Sheikh, Jerome L. Gabriel, Roshantha A.S. Chandraratna, Kenneth J. Soprano, Devendra M. Kochhar

Journal:

Toxicology and Applied Pharmacology

Year:

2001

Language:

english

File:

PDF, 185 KB

english, 2001

45

Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid

Devendra M. Kochhar, Heng Jiang, John D. Penner, Richard L. Beard, Roshantha A.S. Chandraratna

Journal:

Chemico-Biological Interactions

Year:

1996

Language:

english

File:

PDF, 561 KB

english, 1996

46

Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells

László Nagy, Vilmos A. Thomázy, Roshantha A.S. Chandraratna, Richard A. Heyman, Peter J.A. Davies

Journal:

Leukemia Research

Year:

1996

Language:

english

File:

PDF, 2.04 MB

english, 1996

47

Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents

Andrew M. Standeven, Scott M. Thacher, Yang-Dar Yuan, Maria Escobar, Vidyasagar Vuligonda, Richard L. Beard, Roshantha A.S. Chandraratna

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 133 KB

english, 2001

48

Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes

Ulrich Kintscher, Stephan Goetze, Shu Wakino, Sarah Kim, Sunil Nagpal, Roshantha A.S Chandraratna, Kristof Graf, Eckart Fleck, Willa A Hsueh, Ronald E Law

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 1.16 MB

english, 2000

49

Novel approaches for the treatment of psoriasis

Daniel DiSepio, Roshantha A.S. Chandraratna, Sunil Nagpal

Journal:

Drug Discovery Today

Year:

1999

Language:

english

File:

PDF, 251 KB

english, 1999

50

Retinoid Signaling Is Required for Chondrocyte Maturation and Endochondral Bone Formation during Limb Skeletogenesis

Eiki Koyama, Eleanor B. Golden, Thorsten Kirsch, Sherrill L. Adams, Roshantha A.S. Chandraratna, Jean-Jacques Michaille, Maurizio Pacifici

Journal:

Developmental Biology

Year:

1999

Language:

english

File:

PDF, 913 KB

english, 1999

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